F40. NEUREXIN-1α (NRNX1α) HYPOFUNCTION INDUCES SCHIZOPHRENIA-RELEVANT DEFICITS IN CEREBRAL METABOLISM, COGNITIVE PROCESSING SPEED AND COGNITIVE FLEXIBILITY
نویسندگان
چکیده
منابع مشابه
Modafinil reverses phencyclidine-induced deficits in cognitive flexibility, cerebral metabolism, and functional brain connectivity.
OBJECTIVE In the present study, we employ mathematical modeling (partial least squares regression, PLSR) to elucidate the functional connectivity signatures of discrete brain regions in order to identify the functional networks subserving PCP-induced disruption of distinct cognitive functions and their restoration by the procognitive drug modafinil. METHODS We examine the functional connectiv...
متن کاملCognitive Flexibility, Attention and Speed of Mental Processing in Opioid and Methamphetamine Addicts in Comparison with Non-Addicts
Introduction: Many studies have revealed that drug addicted individuals exhibit impaired performance on executive function tests but a few studies have been conducted on executive functions of drug addicts in Iran. To contribute to this understanding, the present study was designed to assess some domains related to executive functions including cognitive flexibility, attention and speed of men...
متن کاملSchizophrenia: Cognitive Deficits and Perceptual Deficits
Schizophrenia is a complex and severe mental disorder that affects about 1% of the population, clinically characterized by positive, negative, and disorganized symptoms. It is widely accepted that a combination of genetic and environmental factors lead to the onset of schizophrenia. The past two decades have witnessed the increasingly important role of cognitive deficits in schizophrenia, such ...
متن کاملCognitive processing in schizophrenia
I read the short report by Hall et al (2004) with interest. The authors reported a marked impairment in the ability of people with schizophrenia to make social judgements from facial expressions. Their findings complement and extend earlier studies by us and others (Hellewell et al, 1994; Edelstyn et al, 1996, 2003) that have reported the presence of impairments in facial recognition memory. Ho...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2018
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sby017.571